Imidocarb 2
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چکیده
2. The mode of action of imidocarb is uncertain though two mechanisms have been proposed: interference with the production and/or utilisation of polyamines, or prevention of entry of inositol into the erythrocyte containing the parasite. In a general pharmacological screen, mice were given single subcutaneous doses of imidocarb dihydrochloride; myosis was observed at 50 mg/kg bw but mydriasis at 150 mg/kg bw. In another study, cardiovascular and neuromuscular effects, attributable in part to the anticholinesterase effect of imidocarb, were observed following intravenous administration of dihydrochloride to cats and dogs. No overall conclusions could be drawn regarding a pharmacological NOEL.
منابع مشابه
Equine piroplasmosis treatment protocols: specific effect on orocaecal transit time as measured by the lactose 13C-ureide breath test.
REASONS FOR PERFORMING STUDY Imidocarb dipropionate is the drug of choice for equine piroplasmosis but its administration causes severe colic and diarrhoea. An imidocarb protocol that reduces these effects is needed. OBJECTIVES 1) Quantification of the effects of imidocarb dipropionate on equine orocaecal transit time (OCTT), with and without atropine or glycopyrrolate premedication and 2) in...
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Four chemotherapeutic trials in Iran with the babesicide 3,3-bis(2-imidazoline-2-yl) carbanilide dihydrochloride (Imidocarb dihydrochloride) are reported. Subcutaneous administration at a dose of l mg/kg proved highly effective in controlling experimental infection with a local virulent strain of Babesia bigemina in calves. While treated calves were apparently sterilized of the infection, they ...
متن کاملEffect of Imidocarb dipropionate on the immune response to Foot and Mouth Disease vaccine in healthy and anaplasmosis-infected calves
Aim: This work was performed to investigate the effect of a potent anti-protozoan drug, Imidocarb on the cell mediated and humoral immune response to foot and mouth disease vaccine (FMDV, O strain) in normal and Anaplasmosis-infected calves. 1 Materials and Methods: A total of 55 male mixed bred calves were used and divided into two main groups of 25 calves each. The first group was healthy and...
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